Neoprene Orthopaedic Supports: An Underrecognised Cause of Allergic Contact Dermatitis

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Neoprene Orthopaedic Supports: An Underrecognised Cause of Allergic Contact Dermatitis

Thioureas, often contained within neoprene to provide water resistance, are an important cause of allergic contact dermatitis (ACD) in those who use neoprene products. We wish to present three cases of thiourea-induced ACD from three different orthopaedic supports containing neoprene. The first case was a 67-year-old woman who developed an itchy rash on her heel three weeks after using a neopre...

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Targeted testing with diethylthiourea often reveals clinically relevant allergic contact dermatitis caused by neoprene rubber.

BACKGROUND Diethylthiourea is widely used in the rubber industry, particularly in neoprene rubber, and may cause allergic contact dermatitis. However, as thiourea allergens are not part of the European baseline series, the diagnosis of allergic contact dermatitis caused by thiourea compounds depends on clinical suspicion and aimed testing. OBJECTIVES The aims of this study were to evaluate th...

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Allergic Contact Dermatitis Physiology

Allergic Contact Dermatitis (ACD) involves the penetration of an allergen through the skin surface where it acts as a hapten by binding to epidermal proteins and eliciting, a delayed Type IV hypersensitivity reaction 48 to 120 hours after exposure. This immunologic response involves the activation of Th1 cells with the subsequent release of cytokines resulting in the classic inflammatory reaction.

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Allergic contact dermatitis

Allergic contact dermatitis is a T cell mediated, antigen-specific inflammatory reaction of the skin due to repeated epicutaneous exposure to antigens. Immunologically it is divided into 2 phases, induction and elicitation phase. During the first phase which is clinically silent, naïve T cells are activated and differentiate into antigen-specific memory T cells. During the elicitation phase, af...

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Allergic contact dermatitis.

Allergic contact dermatitis (ACD) is a common occupational and environmental health issue. In common with other forms of allergy the disease progresses in two stages; an initial phase during which sensitization is acquired, followed later (after subsequent exposure to the same chemical allergen) by elicitation of a cutaneous inflammatory reaction. The development of skin sensitization is associ...

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ژورنال

عنوان ژورنال: Case Reports in Orthopedics

سال: 2015

ISSN: 2090-6749,2090-6757

DOI: 10.1155/2015/496790